HIV Neurodegenerative Mechanisms Compared to Other Neurodegenerative Diseases – by Valquíria M. de Figueiredo, Tiago A. O. Silva

HIV Neurodegenerative Mechanisms Compared to Other Neurodegenerative Diseases – by Valquíria Merjan de Figueiredo, Tiago Andrade de Oliveira e Silva   Introduction This article describes HIV-1 factors and mechanisms involved in neurodegeneration and compares them with those of other neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s disease. According to… Continue lendo…

HIV INFECTION AND DRUG ABUSE: IMPLICATIONS FOR NEUROPLASTICITY AND NEUROCOGNITIVE DISORDERS – Mônica Bento Bispo Patrícia de Barros Viegas

(Mônica Bento Bispo Patrícia de Barros Viegas) INTRODUCTION   Human immunodeficiency virus-1 (HIV-1) neuroinvasion occurs in about 80 % of infected individuals (Persidsky and Poluektova, 2006). In the early stage of infection, HIV enters the central nervous system (CNS) via infected monocytes, macrophages and T cells that cross the blood-brain… Continue lendo…

The role of dopaminergic dysfunction as an etiological factor in HIV-associated cognitive deficits and how it can be tested in animal models-by Francisco Catsarini, Jaume Aran and Marineide Aquino

  A major consequence of HIV infection is the development of cognitive deficits due to the effects of infection on the CNS. These deficits, usually referred to as HAND (HIV Associated Neurocognitive Disorders), are commonly classified in three categories, according to their severity: asymptomatic, mild and dementia. Although highly active… Continue lendo…